Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ... Oct 29, 2020 · Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ... The Crossword Solver found 60 answers to "plague", 4 letters crossword clue. The Crossword Solver finds answers to classic crosswords and cryptic crossword puzzles. Enter the length or pattern for better results. Click the answer to find similar crossword clues . Enter a Crossword Clue.Bubonic plague can advance and spread to the lungs, which is the more severe type of plague called Pneumonic plague. Pneumonic plague – or lung-based plague – is the most virulent form of plague. Incubation can be as short as 24 hours. Any person with pneumonic plague may transmit the disease via droplets to other humans.Jul 22, 2021 · The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ... Nov 15, 2021 · Septicemic plague can occur as the first symptom of plague or may develop from untreated bubonic plague. This form results from bites of infected fleas or from handling an infected animal. Pneumonic plague: The incubation period of pneumonic plague is usually just 1 to 3 days. Patients develop fever, headache, weakness, and a rapidly developing ... New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD)Plague definition, an epidemic disease that causes high mortality; pestilence. See more. Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. Before covid-19, this was the world’s most recent pandemic, infecting as much as 21 percent of the world’s population. Swine flu was a hodgepodge of several different flu strains that had ...The bubonic plague was the most commonly seen form during the Black Death, with a mortality rate of 30-75% and symptoms including fever of 38 - 41 °C (101-105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Of those who contracted the bubonic plague, 4 out of 5 died within eight days. How to pronounce plague. How to say plague. Listen to the audio pronunciation in the Cambridge English Dictionary. Learn more. plague n. (infestation of insects or rats) invasion nf. (de moustiques, sauterelles,...) nuée nf. The citizens of Hamlin called on the services of the Pied Piper because of a plague of rats. Les citoyens de la ville de Hamelin ont fait appel au service du joueur de flûte à cause d'une invasion de rats. plague n.The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600.Collection. by Mark Cartwright. published on 26 March 2020. Plagues have swept through humanity ever since communities have gathered together in concentrated groups. In this collection of resources, we look at just some of the pandemics that raged throughout Antiquity and the Middle Ages, from the plague that ripped through Athens in the 5th ...Sep 24, 2020 · History of Plague Epidemics. The plague has afflicted humanity for thousands of years.1, 2, 3 Molecular studies identified the presence of the Y. pestis plague DNA genome in 2 Bronze Age skeletons dated at roughly 3800 years old. 9 In the biblical book 1 Samuel from approximately 1000 BCE, the Philistines experience an outbreak of tumors associated with rodents, which might have been bubonic ... Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms.Feb 28, 2022 · The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ... Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. plague n. (infestation of insects or rats) invasion nf. (de moustiques, sauterelles,...) nuée nf. The citizens of Hamlin called on the services of the Pied Piper because of a plague of rats. Les citoyens de la ville de Hamelin ont fait appel au service du joueur de flûte à cause d'une invasion de rats. plague n.Plague is a serious infectious disease that affects mammals, including humans. It can spread through animal or human contact. The bacteria that cause plague live in many parts of the world ...Nov 22, 2021 · The Moscow Plague. The Moscow plague hit the earth in 1770. It mainly impacted the Moscow people. And, it was believed to be a replication of the bubonic plague. The plague killed an average of 50 ... The bubonic plague was the most commonly seen form during the Black Death, with a mortality rate of 30-75% and symptoms including fever of 38 - 41 °C (101-105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Of those who contracted the bubonic plague, 4 out of 5 died within eight days. Plague. Plague, caused by the bacterium Yersinia pestis, is a disease that affects humans and other mammals. People typically get infected after being bitten by a rodent flea that is carrying the bacterium or by handling a plague-infected animal. Although the disease killed millions in Europe during the Middle Ages, antibiotics effectively ...plague ý nghĩa, định nghĩa, plague là gì: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Tìm hiểu thêm.The bubonic plague was the most commonly seen form during the Black Death, with a mortality rate of 30-75% and symptoms including fever of 38 - 41 °C (101-105 °F), headaches, painful aching joints, nausea and vomiting, and a general feeling of malaise. Of those who contracted the bubonic plague, 4 out of 5 died within eight days. What is plague? Plague is a disease caused by Yersinia pestis that affects rodents (e.g., squirrels, prairie dogs, or mice), other mammals (e.g., rabbits or hares), and humans. These bacteria are found in many areas of the world, including the western United States. There are three forms of plague: bubonic (lymph node infection), pneumonic (lung […] plague definition: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Learn more. The Justinian Plague of 541-544 . The first great pandemic of bubonic plague where people were recorded as suffering from the characteristic buboes and septicaemia was the Justinian Plague of 541 CE, named after Justinian I, the Roman emperor of the Byzantine Empire at the time. The epidemic originated in Ethiopia in Africa and spread to ...There are three kinds of Plague disease: Bubonic plague disease – It is an infection in the lymph nodes of the body. The lymph nodes swell and cause serious pain and it is transmitted through the fleas that contain the bacteria. Pneumonic plague disease – It is a contagious disease that causes infection in the lungs.May 7, 2020 · The plague as an actual event figures prominently in only one of Shakespeare’s plays. Friar Laurence in “Romeo and Juliet” has asked a fellow friar to deliver a crucial message to the exiled ... Plague is a serious illness caused by a germ called Yersinia pestis. The germs mostly live in small rodents and their fleas. The most common way for humans to get plague is a flea bite. Plague is a rare disease. The illness mostly occurs in only a few countries around the world.The Black Death was a bubonic plague pandemic, which reached England in June 1348. It was the first and most severe manifestation of the second pandemic, caused by Yersinia pestis bacteria. The term Black Death was not used until the late 17th century. Originating in Asia, it spread west along the trade routes across Europe and arrived on the ...Play Plague Inc. Online in Browser. Plague Inc. is a simulation game developed by Miniclip.com and now.gg allows playing game online in your browser. There are many more interesting online games that you can explore here. READ MORE FAQs.Synonyms for PLAGUE: afflict, persecute, torture, besiege, curse, attack, beset, torment; Antonyms of PLAGUE: help, aid, assist, relieve, release, deliver, abet, comfort Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. Plagues of Egypt. Scenes from the book of Exodus: The death of the firstborns (including the Pharaoh 's son), and the Israelites leaving Egypt ( Haggadah shel Pesaḥ, 1325–1374 CE, Barcelona via British Library) The Plagues of Egypt, in the account of the book of Exodus, are ten disasters inflicted on Biblical Egypt by the God of Israel in ... Responding to a Plague Bioterrorism Event. Kettles, buckets, lanterns, and other equipment were used in catching rats during the Public Health Service campaign against the New Orleans plague epidemic of 1914-1920. (Library of Medicine) Page last reviewed: February 7, 2022. Content source: Centers for Disease Control and Prevention, National ...Definition of plague. a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal; an annoyance; "those children are a damn plague"; any epidemic disease with a high death rate; any large scale calamity (especially when thought to be sent by God) Nov 27, 2018 · New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD) plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune. The Plague Runeword is a Weapon Runeword in Diablo II: Resurrected Patch 2.7 & Ladder Season 4, introduced in the Patch 2.4 Ladder Season 1. In this guide, we will give you quick facts about Plague, strengths and weaknesses, best classes and specs, best Mercenary use, best socketed base items to use to create this Runeword, and hints for farming the necessary Runes.plague: [noun] a disastrous evil or affliction : calamity. a destructively numerous influx or multiplication of a noxious animal : infestation. Florida Health. Disease Control. [email protected]. 850-245-4444. Florida Health. 4052 Bald Cypress Way. Tallahassee, FL 32399. Plague is an acute, bacterial disease caused by Yersinia pestis, a Gram-negative bacteria that is transmitted from rodent to rodent by infected fleas.The plague as an actual event figures prominently in only one of Shakespeare’s plays. Friar Laurence in “Romeo and Juliet” has asked a fellow friar to deliver a crucial message to the exiled ...Sep 4, 2023 · Pneumonic plague affects the lungs and causes symptoms similar to those of severe pneumonia: fever, weakness, and shortness of breath. Fluid fills the lungs and can cause death if untreated. Other symptoms may include insomnia, stupor, a staggering gait, speech disorder, and loss of memory. Septicemic plague is an infection of the blood. Its ... Black Death. The Black Death (also known as the Pestilence, the Great Mortality or the Plague) [a] was a bubonic plague pandemic occurring in Western Eurasia and North Africa from 1346 to 1353. It is the most fatal pandemic recorded in human history, causing the deaths of 75–200 million people, [1] peaking in Europe from 1347 to 1351.Plague is an infectious disease caused by the bacteria Yersinia pestis, a zoonotic bacteria, usually found in small mammals and their fleas. It is transmitted between animals from their fleas. Humans can be contaminated by the bite of infected fleas, through direct contact with infected materials or by inhalation.plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune.plague ý nghĩa, định nghĩa, plague là gì: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Tìm hiểu thêm.What is plague? Plague is a disease caused by Yersinia pestis that affects rodents (e.g., squirrels, prairie dogs, or mice), other mammals (e.g., rabbits or hares), and humans. These bacteria are found in many areas of the world, including the western United States. There are three forms of plague: bubonic (lymph node infection), pneumonic (lung […]List of epidemics and pandemics. 17th-century German "plague panel" depicting the triumph of death. Panels of this kind were placed on the walls of houses to warn against the plague. A plague epidemic raged in Augsburg, Bavaria, between 1632 and 1635. This is a list of the largest known epidemics and pandemics caused by an infectious disease.Nov 27, 2018 · New plague vaccines are in development but are not expected to be commercially available in the immediate future. Page last reviewed: November 27, 2018 Content source: Centers for Disease Control and Prevention , National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) , Division of Vector-Borne Diseases (DVBD) Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ...Black Death, pandemic that ravaged Europe between 1347 and 1351, taking a proportionately greater toll of life than any other known epidemic or war up to that time. The Black Death is widely thought to have been the result of plague, caused by infection with the bacterium Yersinia pestis.Jul 9, 2021 · Bioterrorism. Plague is an infectious disease that can cause serious illness in people living in rural areas of the western United States and parts of Africa, Asia, and South America. It is caused by the bacteria Yersinia pestis, and people usually get plague after being bitten by an infected flea or handling an infected animal. It is possible ... Bioterrorism. Plague is an infectious disease that can cause serious illness in people living in rural areas of the western United States and parts of Africa, Asia, and South America. It is caused by the bacteria Yersinia pestis, and people usually get plague after being bitten by an infected flea or handling an infected animal. It is possible ...Define plague. plague synonyms, plague pronunciation, plague translation, English dictionary definition of plague. ) n. 1. a. A highly infectious epidemic disease ... "Plague is a must-read book so revolutionary in its implications that its author courageously faced character assassination and unlawful incarceration to keep her findings from being relegated to the dustbin of medical history. Riveting, if not at times paradigm shifting, this book reveals a dark side to modern mediSep 4, 2023 · Pneumonic plague affects the lungs and causes symptoms similar to those of severe pneumonia: fever, weakness, and shortness of breath. Fluid fills the lungs and can cause death if untreated. Other symptoms may include insomnia, stupor, a staggering gait, speech disorder, and loss of memory. Septicemic plague is an infection of the blood. Its ... The Plague Runeword is a Weapon Runeword in Diablo II: Resurrected Patch 2.7 & Ladder Season 4, introduced in the Patch 2.4 Ladder Season 1. In this guide, we will give you quick facts about Plague, strengths and weaknesses, best classes and specs, best Mercenary use, best socketed base items to use to create this Runeword, and hints for farming the necessary Runes.11 hours ago · Since the Act was enacted in 1966, NHTSA has recalled more than 390 million cars, trucks, buses, recreational vehicles, motorcycles, and mopeds. From 2018 through 2022 there were about 32 million ... Bubonic plague can advance and spread to the lungs, which is the more severe type of plague called Pneumonic plague. Pneumonic plague – or lung-based plague – is the most virulent form of plague. Incubation can be as short as 24 hours. Any person with pneumonic plague may transmit the disease via droplets to other humans.Plague is transmitted between animals and humans by the bite of infected fleas, direct contact with infected tissues, and inhalation of infected respiratory droplets. Plague can be a very severe disease in people, with a case-fatality ratio of 30% to 60% for the bubonic type, and is always fatal for the pneumonic kind when left untreated.The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ...Plague is an infectious disease caused by the bacteria Yersinia pestis, a zoonotic bacteria, usually found in small mammals and their fleas. It is transmitted between animals from their fleas. Humans can be contaminated by the bite of infected fleas, through direct contact with infected materials or by inhalation.Synonyms for PLAGUE: afflict, persecute, torture, besiege, curse, attack, beset, torment; Antonyms of PLAGUE: help, aid, assist, relieve, release, deliver, abet, comfortBefore covid-19, this was the world’s most recent pandemic, infecting as much as 21 percent of the world’s population. Swine flu was a hodgepodge of several different flu strains that had ...Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. The plague is a serious bacterial infection that can be deadly. Sometimes referred to as the “black plague,” the disease is caused by a bacterial strain called Yersinia pestis.This bacterium ...Background. There are three types of plague. Most of the sick in 1665-1666 had bubonic plague. This created swellings (buboes) in the lymph nodes found in the armpits, groin and neck. Plague sufferers experienced headaches, vomiting and fever. They had a 30% chance of dying within two weeks.Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. The Black Death of 1347-1352 CE is the most infamous plague outbreak of the medieval world, unprecedented and unequaled until the 1918-1919 CE flu pandemic in the modern age. The cause of the plague was unknown and, in accordance with the general understanding of the Middle Ages, was attributed to supernatural forces and, primarily, the will or ...Treatment for plague begins as soon as the health care provider suspects the disease. Treatment is typically done in the hospital. Antibiotics that may be used include the following: Gentamicin. Doxycycline (Monodox, Vibramycin, others). Ciprofloxacin (Cipro). Levofloxacin. Moxifloxacin (Avelox). Chloramphenicol.Explore the history of the European plague doctor, and find out where their iconic outfit of a beaked mask and robe came from.--The year is 1656. Your body i...Apr 20, 2023 · Plague symptoms are sudden and serious. If you are coughing or sneezing, you should wear a mask. You will likely go to an emergency room. If plague is suspected, you'll see a specialist in infectious disease. What you can do. If you are helping a person with plague-like symptoms, you can prepare for the appointment by taking the following steps: Jul 22, 2021 · The 10-year-old child who died of plague earlier this month was a La Plata County resident. Plague is caused by bacteria and usually is transmitted by bites from infected fleas. Prairie dogs ... The plague is treatable in humans and animals if caught and addressed early. CBSN Denver noted that last year, two people in Colorado were confirmed to have contracted the plague, and both survived.Plague is an infectious disease caused by the bacterium Yersinia pestis. Symptoms include fever, weakness and headache. Usually this begins one to seven days after exposure. There are three forms of plague, each affecting a different part of the body and causing associated symptoms. Over 80% of United States plague cases have been the bubonic form. In recent decades, an average of seven human plague cases have been reported each year (range: 1–17 cases per year). Plague has occurred in people of all ages (infants up to age 96), though 50% of cases occur in people ages 12–45. It occurs in both men and women, though ...Plague Inc. is a unique mix of high strategy and terrifyingly realistic simulation with over 700 million games played! Your pathogen has just infected 'Patient Zero'. Now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.plague ý nghĩa, định nghĩa, plague là gì: 1. to cause worry, pain, or difficulty to someone or something over a period of time: 2. to annoy…. Tìm hiểu thêm.Nov 15, 2021 · Septicemic plague can occur as the first symptom of plague or may develop from untreated bubonic plague. This form results from bites of infected fleas or from handling an infected animal. Pneumonic plague: The incubation period of pneumonic plague is usually just 1 to 3 days. Patients develop fever, headache, weakness, and a rapidly developing ... Nov 26, 2019 · Plague is a plausible diagnosis for people who are sick and live in, or have recently traveled to, the western United States or any other plague-endemic area. The most common sign of bubonic plague is the rapid development of a swollen and painful lymph gland called a bubo. A known flea bite or the presence of a bubo may help a doctor to ... Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ... plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune.
Nov 22, 2021 · The Moscow Plague. The Moscow plague hit the earth in 1770. It mainly impacted the Moscow people. And, it was believed to be a replication of the bubonic plague. The plague killed an average of 50 ... . H5322 031
Plague definition, an epidemic disease that causes high mortality; pestilence. See more. Plagues of Egypt. Scenes from the book of Exodus: The death of the firstborns (including the Pharaoh 's son), and the Israelites leaving Egypt ( Haggadah shel Pesaḥ, 1325–1374 CE, Barcelona via British Library) The Plagues of Egypt, in the account of the book of Exodus, are ten disasters inflicted on Biblical Egypt by the God of Israel in ... a. : an epidemic disease causing a high rate of mortality : pestilence. b. : a virulent contagious febrile disease that is caused by a bacterium (Yersinia pestis) and that occurs in bubonic, pneumonic, and septicemic forms. called also black death. 3. a.Definition of plague. a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal; an annoyance; "those children are a damn plague"; any epidemic disease with a high death rate; any large scale calamity (especially when thought to be sent by God)Nov 26, 2019 · Plague is a plausible diagnosis for people who are sick and live in, or have recently traveled to, the western United States or any other plague-endemic area. The most common sign of bubonic plague is the rapid development of a swollen and painful lymph gland called a bubo. A known flea bite or the presence of a bubo may help a doctor to ... Plague is an infectious disease caused by the bacteria Yersinia pestis, a zoonotic bacteria, usually found in small mammals and their fleas. It is transmitted between animals from their fleas. Humans can be contaminated by the bite of infected fleas, through direct contact with infected materials or by inhalation.Plague is a febrile illness that typically manifests into one or more clinical syndromes, often reflecting the route of exposure to the bacterium. These clinical syndromes include bubonic, septicemic, and pneumonic plague. Several classes of antibiotics are effective against plague. Plague can be rapidly fatal if appropriate antimicrobial ...plague of [sth] n. figurative ( [sth] bad and persistent) serie, ondata nf. Anna has suffered a plague of misfortunes. Anna è stata vittima di una serie di disgrazie. plague [sb/sth] ⇒ vtr. figurative, often passive (afflict) (figurato) flagellare ⇒ vtr. That country has been plagued by misfortune.People infected with plague usually develop influenza-like symptoms after an incubation period of 3–7 days. Symptoms include fever, chills, aches, weakness, vomiting and nausea. There are 3 main forms of plague. Bubonic plague is the most common and is caused by the bite of an infected flea.Responding to a Plague Bioterrorism Event. Kettles, buckets, lanterns, and other equipment were used in catching rats during the Public Health Service campaign against the New Orleans plague epidemic of 1914-1920. (Library of Medicine) Page last reviewed: February 7, 2022. Content source: Centers for Disease Control and Prevention, National ...Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. Aug 29, 2023 · The Latin word also is the source of Old Irish plag (genitive plaige) "plague, pestilence," German Plage, Dutch plaage. Meaning "epidemic that causes many deaths" is from 1540s; specifically in reference to bubonic plague from c. 1600. Modern spelling follows French, which had plague from 15c. Weakened sense of "anything annoying" is from c. 1600. .